I Also Owe My Career To Muslim Immigrant Scientists

David Kroll wrote a great piece for Forbes today where he detailed how Muslim scientists played prominently in all stages of his career.

I have had a very similar experience, especially as a faculty member. They were essential contributors to my grants, my papers, and my career advancement. They were kind enough to invite me and the other lab members to Iftar at the local Islamic Center. They invited me into their homes and hearts. I consider them part of my family. It disgusts me to know that they are afraid and no longer feel welcome in this country. As Dr. Kroll suggested, scientists should loudly denounce the downright disgusting and xenophobic/islamophobic rhetoric being discussed in certain political circles, especially by the Republican front-runner Donald Trump. I join him in noting that Muslims are a essential component of the biomedical research community in the United States. In addition to this pragmatic point, I would also note that this is an issue of basic human decency. Discriminating against an entire religion is about as awful and un-American as you can get.

Below is a partial listing of the exceptional science accomplished by Muslim immigrant scientists in my laboratory in just the past five years. I am deeply grateful for all of their contributions, both professional and personal.

Borahay MA, Al-Hendy A, Kilic GS, Boehning D. Signaling Pathways in Leiomyoma: Understanding Pathobiology and Implications for Therapy. Mol Med. 2015 Apr 13;21:242-56. doi: 10.2119/molmed.2014.00053. PubMed PMID: 25879625; PubMed Central PMCID: PMC4503645.

Borahay MA, Vincent K, Motamedi M, Sbrana E, Kilic GS, Al-Hendy A, Boehning D. Novel effects of simvastatin on uterine fibroid tumors: in vitro and patient-derived xenograft mouse model study. Am J Obstet Gynecol. 2015 Aug;213(2):196.e1-8. doi: 10.1016/j.ajog.2015.03.055. Epub 2015 Mar 31. PubMed PMID: 25840272; PubMed Central PMCID: PMC4519389.

Borahay MA, Kilic GS, Yallampalli C, Snyder RR, Hankins GD, Al-Hendy A,
Boehning D. Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells. J Biol Chem. 2014 Dec 19;289(51):35075-86. doi: 10.1074/jbc.M114.583575. Epub 2014 Oct 30. PubMed PMID: 25359773; PubMed Central PMCID: PMC4271198.

Safren N, El Ayadi A, Chang L, Terrillion CE, Gould TD, Boehning DF, Monteiro MJ. Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington’s disease. PLoS One. 2014 Jan 27;9(1):e87513. doi: 10.1371/journal.pone.0087513. eCollection 2014.PubMed PMID: 24475300; PubMed Central PMCID: PMC3903676.

El Ayadi A, Stieren ES, Barral JM, Boehning D. Ubiquilin-1 and protein qualitycontrol in Alzheimer disease. Prion. 2013 Mar-Apr;7(2):164-9. doi:
10.4161/pri.23711. Epub 2013 Jan 29. PubMed PMID: 23360761; PubMed Central PMCID: PMC3609125.

Wang X, Xiong LW, El Ayadi A, Boehning D, Putkey JA. The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release. J Biol Chem. 2013 Jan 18;288(3):2040-8. doi: 10.1074/jbc.M112.411314. Epub 2012 Nov 30. PubMed PMID: 23204517; PubMed Central PMCID: PMC3548510.



El Ayadi A, Stieren ES, Barral JM, Oberhauser AF, Boehning D. Purification and aggregation of the amyloid precursor protein intracellular domain. J Vis Exp. 2012 Aug 28;(66):e4204. doi: 10.3791/4204. PubMed PMID: 22952038; PubMed Central PMCID: PMC3478677.

El Ayadi A, Stieren ES, Barral JM, Boehning D. Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13416-21. doi: 10.1073/pnas.1206786109. Epub 2012 Jul 30. PubMed PMID: 22847417; PubMed Central PMCID: PMC3421158.

Stieren ES, El Ayadi A, Xiao Y, Siller E, Landsverk ML, Oberhauser AF, Barral JM, Boehning D. Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein. J Biol Chem. 2011 Oct 14;286(41):35689-98. doi: 10.1074/jbc.M111.243147. Epub 2011 Aug 18. PubMed PMID: 21852239; PubMed Central PMCID: PMC3195644.

Stieren E, Werchan WP, El Ayadi A, Li F, Boehning D. FAD mutations in amyloid precursor protein do not directly perturb intracellular calcium homeostasis. PLoS One. 2010 Aug 5;5(8):e11992. doi: 10.1371/journal.pone.0011992. PubMed PMID: 20700539; PubMed Central PMCID: PMC2916833.


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